“芯片上的蠕蟲”可無創診斷肺癌

2026-03-27 10:51:18 來源:環球網 閱讀數:1876

狗(gou)擁(yong)有(you)令(ling)人(ren)難(nan)以(yi)置(zhi)信(xin)的(de)嗅(xiu)覺(jiao),在(zai)實(shi)驗(yan)室(shi)中(zhong),一(yi)種(zhong)更(geng)簡(jian)單(dan)的(de)生(sheng)物(wu)秀(xiu)麗(li)隱(yin)杆(gan)線(xian)蟲(chong),可(ke)通(tong)過(guo)追(zhui)蹤(zong)氣(qi)味(wei)軌(gui)跡(ji)向(xiang)癌(ai)細(xi)胞(bao)蠕(ru)動(dong)。近(jin)日(ri)在(zai)美(mei)國(guo)化(hua)學(xue)學(xue)會(hui)春(chun)季(ji)會(hui)議(yi)上(shang),韓(han)國(guo)明(ming)知(zhi)大(da)學(xue)研(yan)究(jiu)人(ren)員(yuan)報(bao)告(gao)了(le)一(yi)種(zhong)使(shi)用(yong)蠕(ru)蟲(chong)檢(jian)測(ce)肺(fei)癌(ai)細(xi)胞(bao)的(de)裝(zhuang)置(zhi)。這(zhe)種(zhong)“芯片上的蠕蟲”有朝一日可幫助醫生在早期無創診斷癌症。

muqian,yishengtongguoyingxiangxuejianzhahuohuozuzhijianzhalaizhenduanfeiai,danzhexiefangfatongchangwufazaizaoqijieduanjiancedaozhongliu。yinci,yanjiurenyuanjuedingshiyongxiuliyinganxianchongkaifafeiqinruxingaizhengzhenduanfangfa,yinweizhezhongruchonghenxiao(約1毫米長),易於在實驗室中生長並具有非凡的嗅覺。

與(yu)正(zheng)常(chang)細(xi)胞(bao)相(xiang)比(bi),肺(fei)癌(ai)細(xi)胞(bao)會(hui)產(chan)生(sheng)一(yi)組(zu)不(bu)同(tong)的(de)氣(qi)味(wei)分(fen)子(zi),而(er)居(ju)住(zhu)在(zai)土(tu)壤(rang)中(zhong)的(de)秀(xiu)麗(li)隱(yin)杆(gan)線(xian)蟲(chong)會(hui)被(bei)某(mou)些(xie)氣(qi)味(wei)吸(xi)引(yin)或(huo)排(pai)斥(chi),因(yin)此(ci)研(yan)究(jiu)人(ren)員(yuan)將(jiang)線(xian)蟲(chong)放(fang)入(ru)培(pei)養(yang)皿(min)中(zhong)並(bing)添(tian)加(jia)人(ren)的(de)尿(niao)液(ye),可(ke)觀(guan)察(cha)到(dao)線(xian)蟲(chong)優(you)先(xian)爬(pa)向(xiang)癌(ai)症(zheng)患(huan)者(zhe)的(de)尿(niao)液(ye)樣(yang)本(ben)。

yanjiutuanduiyongjuerjiajiguiyangwandanxingtizhizuoleyigexinpian,gaixinpiandemeiyiduandouyouyigekong,tongguotongdaolianjiedaozhongyangqiangshi。yanjiurenyuanjiangxinpianfangzaiqiongzhibanshang。zaixinpiandeyiduan,tamentianjialeyidilaizifeiaixibaodepeiyangji,zailingyiduan,tamentianjialelaizizhengchangfeichengxianweixibaodepeiyangji。tamenjiangruchongfangzhizaizhongyangqiangshizhong,yixiaoshihou,tamenguanchadaobizhengchangpeiyangjigengduoderuchongpaxiangfeiaipeiyangji。xiangbizhixia,juyouodr-3氣味受體基因突變的蠕蟲沒有表現出這種優先行為。

研究人員估計該裝置在檢測稀釋細胞培養基中癌細胞的有效性約為70%。他(ta)們(men)希(xi)望(wang)通(tong)過(guo)使(shi)用(yong)之(zhi)前(qian)暴(bao)露(lu)於(yu)癌(ai)細(xi)胞(bao)培(pei)養(yang)基(ji)的(de)蠕(ru)蟲(chong)來(lai)提(ti)高(gao)該(gai)方(fang)法(fa)的(de)準(zhun)確(que)性(xing)和(he)靈(ling)敏(min)度(du)。通(tong)過(guo)優(you)化(hua)用(yong)於(yu)檢(jian)測(ce)培(pei)養(yang)的(de)肺(fei)癌(ai)細(xi)胞(bao)的(de)芯(xin)片(pian)蠕(ru)蟲(chong),研(yan)究(jiu)團(tuan)隊(dui)計(ji)劃(hua)繼(ji)續(xu)測(ce)試(shi)尿(niao)液(ye)、tuoyeshenzhirenleihuchudeqiti,yiquedinggaifangfashifoukeyizaizaoqijiancehuanzhedefeiai。zaishiyongxinpianruchongdeqitayanjiuzhong,yanjiurenyuanquedinglejiangxiuliyinganxianchongxiyindaofeiaixibaodetedingqiweifenzi,baokuoyizhongmingwei2-乙基-1-己醇的揮發性有機化合物。研究人員猜測,2-乙基-1-己醇的氣味可能類似於它們最喜歡的食物的氣味。

總編輯圈點

秀麗隱杆線蟲是一種無毒無害、可ke以yi獨du立li生sheng存cun的de線xian蟲chong,也ye是shi分fen子zi生sheng物wu學xue和he發fa育yu生sheng物wu學xue研yan究jiu領ling域yu的de模mo式shi生sheng物wu。在zai人ren類lei的de生sheng物wu學xue研yan究jiu史shi上shang,這zhe種zhong微wei小xiao簡jian單dan的de蟲chong子zi,也ye立li下xia了le赫he赫he功gong勞lao——xibaodiaowangxianxiangzuizaojiushizaixianchongzhongbeijieshide。zheci,keyanrenyuanyoufaxian,xianchongnengwenchufeiaixibaodeweidao,bingxiangzheleixibaoyidong。muqian,xinpianruchongzaijiancexishixibaopeiyangjizhongaixibaodeyouxiaoxingyuewei70%,準確度還有待進一步提高。但根據線蟲喜歡的味道進行癌症早期檢測,看來是一條有潛力的道路。

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